Previous attempts to develop an anti-baby pill for men have shown that this is only possible with a strong intervention in the hormonal balance of men. This also affected men's libido and the desire for sexuality declined rapidly. The effect of this combination preparation, based on testosterone and progestogen, was confirmed in a large study by the World Health Organization (WHO) in 2011. At that time, depression was observed in ten percent of men as a result of taking it. Now Australian researchers could have taken a decisive step in developing a largely symptom-free variant.
Scientists at Monash University in Melbourne have switched off two crucial proteins that are responsible for the transport of sperm. This was published on Tuesday in an article in the US magazine Proceedings of the National Academy of Science. In order to prevent transport, the proteins that ensure sperm transport during ejaculation have been changed so that it is virtually “completely male infertile,” explained researcher Sabatino Ventura. This non-hormonal method does not damage the long-term viability of the sperm, nor does it affect the sexual sensation or general health of male mice during the experiment. "The sperm is there, but the muscle is not getting the chemical message to transport it," Ventura explains. In the next step, Ventura, who also worked with scientists from the British University of Leicester in the study, would like to chemically simulate this genetic process so that it can also be released in men with the help of a tablet.
"The next step is now to develop an oral medication that is efficient, safe, and easily reversible." "With the new results, there are now better options for developing a contraceptive that works effectively and, moreover, is not manufactured on a hormonal basis, according to the study authors.
Previous attempts to develop a contraceptive pill for men generally produced sterile sperm. Hormonal agents can also interfere with sexual activity. Ventura is convinced that his method will not affect the man. "When you are a young man and you get to the age you want to have children, you stop taking (the pill) and everything should be fine," the researcher told ABC. (fr)
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